About Antigenics

Antigenics’ mission is to enhance and extend lives through the development of superior health care products for a wide range of cancers and infectious diseases.

Lead Products in Development at Antigenics

Oncophage^® (vitespen; heat shock protein technology). In April 2008, Oncophage was approved in Russia for the treatment of kidney cancer patients at intermediate risk for disease recurrence.

Outside Russia, Oncophage is an investigational patient-specific vaccine designed to treat cancer with the intent of minimizing side effects. Currently being evaluated in clinical trials, treatment with Oncophage is designed to target only cancerous cells — not healthy normal cells. As a result, Oncophage is designed to limit the toxicities associated with traditional broad-acting cancer treatments.

AG-707. An investigational vaccine for genital herpes treatment based on proprietary heat shock protein technology. This off-the-shelf formulation has completed Phase 1 testing.

QS-21. One of the world’s most widely studied immune adjuvants. This investigational adjuvant is being tested in several advanced clinical vaccine programs in partnership with leading pharmaceutical companies.

In the 14 years since its inception, Antigenics has achieved important milestones:

• Advanced six products in clinical trials, including Phase 3 trials
• Built on five technology platforms
• Established a strong intellectual property position in its core technologies
• Antigenics has corporate offices in New York City, and research, development and manufacturing facilities in Lexington, Massachusetts